LETTER TO THE EDITOR High-resolution serum proteomic patterns for ovarian cancer detection
نویسندگان
چکیده
Laboratory of Pathology — National Cancer Institute Clinical Proteomics Program, National Cancer Institute Center for Cancer Research, Bethesda, MD 20892, USA Food and Drug Administration — National Cancer Institute Clinical Proteomics Program, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD 20892, USA National Cancer Institute Biomedical Proteomics Program, Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA
منابع مشابه
A New Hybrid Feature Subset Selection Algorithm for the Analysis of Ovarian Cancer Data Using Laser Mass Spectrum
Introduction: Amajor problem in the treatment of cancer is the lack of an appropriate method for the early diagnosis of the disease. The chemical reaction within an organ may be reflected in the form of proteomic patterns in the serum, sputum, or urine. Laser mass spectrometry is a valuable tool for extracting the proteomic patterns from biological samples. A major challenge in extracting such ...
متن کاملHigh-resolution serum proteomic patterns for ovarian cancer detection.
We read with interest the review article by Conrads et al. (2004) on the use of high-resolution proteomic profiling of serum for ovarian cancer detection, noting in particular the authors’ claims of 100% sensitivity and specificity. Unfortunately, an aspect of the paper causes us great concern, as it suggests the possible presence of substantial experimental bias. The source of our concern is c...
متن کاملFeed Forward Artificial Neural Network: Tool for Early Detection of Ovarian Cancer
Pathological changes in an organ or tissue may be reflected in proteomic patterns in serum. The early detection of cancer is crucial for successful treatment. Some cancers affect the concentration of certain molecules in the blood, which allows early diagnosis by analyzing the blood mass spectrum. It is possible that exclusive serum proteomic patterns could be used to differentiate cancer sampl...
متن کاملHigh-resolution serum proteomic features for ovarian cancer detection.
Serum proteomic pattern diagnostics is an emerging paradigm employing low-resolution mass spectrometry (MS) to generate a set of biomarker classifiers. In the present study, we utilized a well-controlled ovarian cancer serum study set to compare the sensitivity and specificity of serum proteomic diagnostic patterns acquired using a high-resolution versus a low-resolution MS platform. In blinded...
متن کاملData mining techniques for cancer detection using serum proteomic profiling
OBJECTIVE Pathological changes in an organ or tissue may be reflected in proteomic patterns in serum. It is possible that unique serum proteomic patterns could be used to discriminate cancer samples from non-cancer ones. Due to the complexity of proteomic profiling, a higher order analysis such as data mining is needed to uncover the differences in complex proteomic patterns. The objectives of ...
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